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Anabolic Steroids Background: Anabolic steroids are synthetic derivatives of male hormone testosterone that mimic its effects on muscle building and fat burning. Use: Commonly used by athletes, bodybuilders, and individuals seeking to enhance physical appearance and athletic performance. Often abused for prolonged periods, leading to significant health risks. # Anabolic Steroids: A Comprehensive Overview from StatPearls NCBI Bookshelf Anabolic steroids have a rich history rooted in their initial use as synthetic compounds designed to mimic testosterone's muscle-building effects. Over time, their applications expanded beyond mere muscle growth, leading to clinical uses in treating conditions like muscle wasting and certain metabolic disorders. ## Account The development of anabolic steroids began with early experiments by scientists like Albert Hofmann, who synthesized andropaustrans-ene, one of the earliest anabolic compounds. These early iterations were later refined into more potent derivatives, setting the stage for their modern use in clinical settings. While initially intended to combat muscle wasting, anabolic steroids have since been repurposed and are now approved for specific therapeutic uses. ## Bookshelf StatPearls is a valuable resource available through the NCBI Bookshelf, offering concise yet comprehensive information on various clinical topics. Accessible via the NCBI website, StatPearls serves as a trusted repository of evidence-based medical knowledge, ideal for healthcare professionals seeking quick and reliable references. ## Anabolic Steroids Anabolic steroids are synthetic derivatives of testosterone that possess both anabolic (growth-promoting) and androgenic (masculinizing) properties. Their mechanism of action involves binding to androgen receptors, activating gene expression pathways that enhance muscle protein synthesis and fat metabolism. ## Authors & Affiliations Contributions come from esteemed researchers and clinicians across various fields, including endocrinology and pharmacology. Notable affiliations include institutions contributing to the content's accuracy and reliability. ## Continuing Education Activity StatPearls functions as a continuing education resource, offering courses and materials that aid medical professionals in staying updated with clinical knowledge and practices. ## Indications Approved uses of anabolic steroids include treating muscle wasting, osteoporosis, and certain metabolic disorders. Despite their efficacy, off-label use is common, often for performance enhancement, despite regulatory restrictions to prevent misuse. ## Mechanism of Action Anabolic steroids affect target tissues via both genomic and non-genomic pathways, influencing processes like protein synthesis and fat redistribution, thereby promoting muscle growth and recovery. ## Administration Available in oral and injectable forms, dosages vary based on specific indications, with careful consideration of individual patient factors to optimize treatment outcomes. ## Adverse Effects Use of anabolic steroids can lead to severe adverse effects, including hepatotoxicity, cardiovascular risks, and psychiatric issues, necessitating close monitoring and patient education. ## Contraindications Conditions such as liver disease or certain cardiovascular issues contraindicate anabolic steroid use, highlighting the importance of comprehensive patient history assessment. ## Monitoring Regular monitoring includes lab tests for liver function and cholesterol levels to early detect adverse effects, ensuring patient safety and treatment efficacy. ## Toxicity Both acute overdose and chronic misuse can lead to severe health complications, underscoring the need for emergency care and addiction prevention strategies. ## Enhancing Healthcare Team Outcomes Effective team collaboration improves patient management, with shared decision-making enhancing outcomes while addressing ethical considerations related to steroid use. ## Review Questions Engage with multiple-choice questions covering mechanisms, uses, and risks to test comprehensive understanding of anabolic steroid applications and associated challenges. ## References Key references from StatPearls or reputable journals provide evidence-based support for the information presented, ensuring reliable clinical guidance. ## Views Perspectives on anabolic steroids vary, with society weighing ethical concerns against medical benefits. This discussion is crucial for balanced consideration of their use in clinical settings. ## Bulk Download Access StatPearls content via bulk download, enabling offline reference for convenient review and application in clinical practice. ## Related Information Explore additional resources on PubMed to expand knowledge on steroid uses beyond the provided context, aiding deeper understanding of clinical applications. ## Similar Articles in PubMed Find related articles to extend your knowledge base, connecting steroid use with broader medical topics for comprehensive learning. ## Recent Activity Stay updated with new research and guidelines on anabolic steroids through recent activity feeds, ensuring informed clinical practice aligned with current developments. Feel free to visit my website - best anabolic steroids for muscle mass